| Date | Home Team | Result | Away Team | Match Report |
|---|---|---|---|---|
| 4 Sep 2021 | Rochdale | 65-15 | Orrell | |
| 11 Sep 2021 | Cockermouth | 17-19 | Rochdale | Match Report |
| 18 Sep 2021 | Rochdale | 38-25 | Warrington | Match Report |
| 2 Oct 2021 | - | - | ||
| 10 Oct 2021 | Keswick | 24-34 | Rochdale | Match Report |
| 16 Oct 2021 | Rochdale | 19-3 | Leigh | |
| 23 Oct 2021 | Anselmians | 43-21 | Rochdale | Match Report |
| 30 Oct 2021 | Rochdale | 73-0 | St Benedicts | |
| 13 Nov 2021 | Southport | 18-24 | Rochdale | |
| 20 Nov 2021 | Rochdale | 26-13 | Tarleton | |
| 27 Nov 2021 | De La Salle (Salford) | Home Concede | Rochdale | Rochdale awarded 5 points |
| 11 Dec 2021 | Bolton | 0-24 | Rochdale | Match Report |
| 18 Dec 2021 | Rochdale | 31 - 7 | Cockermouth | |
| 8 Jan 2022 | Warrington | 15 - 36 | Rochdale | |
| 15 Jan 2022 | Rochdale | 42 - 10 | Keswick | |
| 22 Jan 2022 | - | - | ||
| 29 Jan 2022 | Leigh | 17 - 31 | Rochdale | |
| 12 Feb 2022 | Rochdale | 9-5 | Anselmians | Match Report |
| 19 Feb 2022 | St Benedicts | 5-38 | Rochdale | Match Report |
| 26 Feb 2022 | Rochdale | 31-7 | Cockermouth | Match Report |
| 5 Mar 2022 | Rochdale | 36-0 | Southport | Match Report |
| 12 Mar 2022 | Tarleton | 7 - 43 | Rochdale | |
| 19 Mar 2022 | Warrington | 15-36 | Rochdale | Match Report |
| 26 Mar 2022 | Rochdale | Away Concede | De La Salle (Salford) | Rochdale awarded 5 points |
| 2 Apr 2022 | Winnington Park | 33-52 | Rochdale | Match Report |
| 9 Apr 2022 | Rochdale | 54-17 | Bolton | Match Report |
| 23 Apr 2022 | Orrell | Home Concede | Rochdale | Rochdale awarded 5 points |
| 30 Apr 2022 | Rochdale | 31-17 | Winnington Park | Match Report |