| Date | Home Team | Result | Away Team | Match Report |
|---|---|---|---|---|
| 4 Sep 2021 | Rochdale | Orrell | ||
| 11 Sep 2021 | Cockermouth | Rochdale | ||
| 18 Sep 2021 | Rochdale | Warrington | ||
| 25 Sep 2021 | Keswick | Rochdale | ||
| 2 Oct 2021 | - | - | ||
| 16 Oct 2021 | Rochdale | Leigh | ||
| 23 Oct 2021 | Anselmians | Rochdale | ||
| 30 Oct 2021 | Rochdale | St Benedicts | ||
| 13 Nov 2021 | Southport | Rochdale | ||
| 20 Nov 2021 | Rochdale | Tarleton | ||
| 27 Nov 2021 | De La Salle (Salford) | Rochdale | ||
| 4 Dec 2021 | Rochdale | Winnington Park | ||
| 11 Dec 2021 | Bolton | Rochdale | ||
| 18 Dec 2021 | Rochdale | Cockermouth | ||
| 8 Jan 2022 | Warrington | Rochdale | ||
| 15 Jan 2022 | Rochdale | Keswick | ||
| 22 Jan 2022 | - | - | ||
| 29 Jan 2022 | Leigh | Rochdale | ||
| 12 Feb 2022 | Rochdale | Anselmians | ||
| 19 Feb 2022 | St Benedicts | Rochdale | ||
| 5 Mar 2022 | Rochdale | Southport | ||
| 12 Mar 2022 | Tarleton | Rochdale | ||
| 26 Mar 2022 | Rochdale | De La Salle (Salford) | ||
| 2 Apr 2022 | Winnington Park | Rochdale | ||
| 9 Apr 2022 | Rochdale | Bolton | ||
| 23 Apr 2022 | Orrell | Rochdale |