| Date | Home Team | Result | Away Team | Match Report |
|---|---|---|---|---|
| 4 Sep 2021 | Rochdale | 18-3 | Chorley | |
| 11 Sep 2021 | Rochdale | 68-7 | Bury | |
| 25 Sep 2021 | Rochdale | - | Leyland | |
| 2 Oct 2021 | Preston Grasshoppers | 18-19 | Rochdale | |
| 9 Oct 2021 | Rochdale | HWO | De La Salle | |
| 30 Oct 2021 | Aspull | 24-17 | Rochdale | |
| 6 Nov 2021 | Rochdale | 32-8 | Leigh | |
| 13 Nov 2021 | Rochdale | 22-12 | Southport | |
| 4 Dec 2021 | Fylde | 17-5 | Rochdale | |
| 11 Dec 2021 | Bolton | 10-38 | Rochdale | |
| 18 Dec 2021 | Rochdale | P-P | Leyland | |
| 15 Jan 2022 | Leyland | 19-20 | Rochdale | |
| 22 Jan 2022 | Rochdale | 33-12 | Preston Grasshoppers | |
| 29 Jan 2022 | Rochdale | 62-5 | Leigh | |
| 5 Feb 2022 | Rochdale | HWO | Chorley | |
| 12 Feb 2022 | Tarleton | 7 - 27 | Rochdale | |
| 19 Feb 2022 | Rochdale | HWO | Aspull | |
| 26 Feb 2022 | Fylde | 41-19 | Rochdale | |
| 5 Mar 2022 | Southport | 14-31 | Rochdale | |
| 12 Mar 2022 | Rochdale | HWO | Tarleton | |
| 2 Apr 2022 | Rochdale | 7-14 | Fylde | |
| 9 Apr 2022 | Rochdale | Bolton | ||
| 23 Apr 2022 | Chorley | Rochdale | ||
| 30 Apr 2022 | Rochdale | Leyland |